Use sp_addextendedproperty system stored procedure
The following example adds a caption property to column PostalCode in table Address
USE AdventureWorks2008R2;
GO
EXEC sp_addextendedproperty
@name = N'Caption',
@value = 'Postal code is a required column.',
@level0type = N'Schema', @level0name = 'Person',
@level1type = N'Table', @level1name = 'Address',
@level2type = N'Column', @level2name = 'PostalCode';
GO
http://msdn2.microsoft.com/en-us/library/ms180047.aspx
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